| | 1.Why is the arterial and venous port positioned in that way?
The unique design of the two compartment header cap and
corresponding groove in the potting compound create two discrete
yet serially connected blood compartments within the fiber bundle.
Think of it as two dialfilters in one device.
Tracing the flowpath within the diafilter will assist with understanding the
“unique” design of the OLpr™ MD 190 and why the arterial and venous
ports are positioned in this fashion.
The blood will flow first through the first compartment which is called the
“annular” blood compartment or the “outer fiber bundle”.
The blood will then be diluted in the mixing header with substitution fluid.
The flow reverses 180° to enter the “core” blood compartment or the
“core filters”. The blood will then exit the OLpr™ MD 190 filter via the
venous blood port.
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| | 2. Will we have a lot of recirculation?
The diafilter design does not contribute to recirculation.
In theory, the admixing of blood would occur due to the admixing of blood
from the vascular access. This can occur with central venous catheters or
the close proximity of the arterial and venous needle placement.
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| | 3. Why is the replacement fluid directly entering the filter?
The “unique” design o f the OLpr™ MD 190 combines post-dilution and
pre-dilution diafiltration. This mid dilution dialfiltration allows substitution
fluid to flow at 200 ml/min. As a result, superior urea clearance of post-
dilution hemodiafiltration and unsurpassed clearance of toxins in the
middle molecule range. | |
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4. What is the priming volume and which side needs to be upright
while priming?
A minimum of 400- 500 ml of priming solution should be used for air
removal with the substitution port (SP) oriented upward. After this initial
priming phase rotate the device so the substitution port (SP) is oriented
down to further assist in air removal. Typically a total of 1000 ml. or 1
liter of priming solution is used. Be certain to prime the device until the
air has been substantially purged from the circuit. Note *Follow any specific manufacturer’s instructions for operation of
equipment and clinic specific protocols. | |
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5. How much blood does the filter hold?
The blood volume is 140 ml.
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6. What type of membrane is it?
The membrane is Polyethersulfone which is a synthetic material.
Membrane Material: Polyethersulfone
Fiber ID/Wall Thickness: 200µ/30µ
Ultrafiltration Coefficient: 90 ml/h/mmHg
Surface Area: 1.9 m²
Blood Volume: 140 ml
Sterilization: EtO/Irradiation
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| | 7. Will this shorten treatment time?
Treatment time is determined on an individual basis and prescribed by a
physician. | |
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8. Can we use it for HD only?
The OLpr™ MD 190 was specifically designed for use in
hemodialfiltration therapy. | |
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This therapy is prescribed by a physician.
9. During treatment which side needs to be upright?
During operation, the blood ports on the OLpr™ MD 190 are oriented up
and the substitution port is oriented down to achieve optimal mixing of
the substitution fluid with blood. | |
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10. During rinseback which side needs to be upright?
During rinseback (washback) the OLpr™ MD 190 is positioned with the
substitution port (SP) oriented up. This will allow for optimal conditions for
blood return. (Refer to Fig 1 located in the Instructions for Use)
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11. What is the urea clearance compared to our current filters?
The OLpr™ MD 190 has excellent urea clearance.
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Clearance (ml/min) in vitro Qb(ml/min) 250 350 450
Qd=600ml/min, Qs=200ml/min
Urea 237 316 365
Creatinine 228 299 342
Phosphate 221 287 326
Vitamin B12 202 257 283
Cytochrome C 177 200 218
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12. How do you remove the dialysate port caps- twist off or pull?
Position the port cap tabs in the center, grasp the port cap and pull off.
This may require a “twisting” motion to place the tabs where you can
easily grasp and remove with a “pulling” motion.
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