Nephros, Inc. : Defining the Future of ESRD Therapy

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The is an advanced proprietary filter specifically designed for use in hemodiafiltration therapy. It uniquely combines post-dilution and pre-dilution diafiltration into one elegant and simple-to-use filter design. As a result, the achieves the superior urea clearance of post-dilution hemodiafiltration, while offering unsurpassed clearance of toxins in the middle-molecule range.

clearance charts

The construction of the is similar to a typical hollow fiber dialyzer, using a single fiber bundle. A ring-shaped groove in the potting compound at one end and a two compartment header cap are used to separate the fiber bundle into two discrete but serially connected blood paths: an outer or annular path (stage 1), and an inner or core path (stage 2). A substitution fluid inlet port is provided on the opposite header to deliver substitution fluid in mid-stage dilution mode.

¹Locatelli, et. al., Comparison of mortality in ESRD patients on convective and diffusive extracorporeal treatments; Kidney Intl 1999; 55: 286-293

²Held et. al., The dose of Hemodialysis and Patient Mortality, Kidney International 1996; 50: 550-556

³Leypoldt, et. al., Effect of Dialysis Membranes and Middle Molecule Removal on Chronic Hemodialysis Patient Survival, Amer. Journal of Kidney Diseases 1999; 33: 349-355

⁴Canaud, et. al., Ultrafiltration and Convective-Based Dialysis Modalities: New Trends and Applications for Renal Replacement Therapy in ESRD Patients, Nephrol Dial Transplant 1999; 14(Suppl 3): 98-105

⁵Canaud, et. al., Hemodiafiltration with On-Line Production of Bicarbonate Infusate; in Baldemus et. al. (eds), Improvements in Dialysis Therapy, Contrib Nephrol; Basel, Karger 1989; 74: 91-100

⁶Maduell, et. al., Change from conventional haemodiafiltration to on-line haemodiafiltration, Nephrol Dial Transplant 1999; 14: 1202-1207

⁷Minutolo, et. al., Postdialytic Rebound of Serum Phosphorus: Pathogenetic and Clinical Insights; J Am Soc Nephrol 2002; 13: 1046-1054.

This product is currently approved for sale in the European Union.
This product is not yet FDA approved for sale in the US.


	Excellent Urea Clearance Applying mid-dilution hemodiafiltration at Q_s=200 ml/min, the achieves equivalent urea clearances when compared to post-dilution HDF using the Fresnius F80 dialyzer.
	Unmatched B₂m Clearance In mid-dilution hemodiafiltration mode at Q_s=200 ml/min, the achieves as much as 100% improvement in ß₂M clearance when compared to the most commonly used high flux dialyzers in post-dilution HDF mode.