“By combining diffusive, convective and adsorptive transfer in the same exchange module, HDF provides the highest clearances of both small and large solutes.”
Canaud B, Bosc JY, Leray-Moraues H, Stec F, Argiles A, Leblanc M, Mion C: On-Line Haemodiafiltration. Safety and Efficacy in Long-Term Clinical Practice: Nephrol Dialysis Transplant 2000; 15(suppl.1):60-7.

“OL-HDF provides marked enhancement of convection volume and enables a significant increase in osteocalcin and ß₂-microglobulin removal.”
Maduell F, Navarro V, Cruz M C, Torregrosa E, Garcia D, Simon V, Ferrero J A : Osteocalcin and Myoglobin Removal in On-Line Hemodialfiltration versus Low and High-Flux Hemodialysis. AJKD 2002 Sep; 40(3):582-589.

“Predialytic serum P levels diminished in HDF (from 5.8±0.2 to 4.4±0.3 mg/dl; P<0.05), but they remained unchanged in HD.”
Minutolo R, Bellizzi V, Cioffi M, Iodice C, Giannattasio P, Andreucci M, Terracciano V, Di Iorio BR, Conte g, De Nicola L : Postdialytic Rebound of Serum Phosphorus: Pathogenetic and Clinical Insights. J Am Soc Nephrol 2002; 13(4):1046-54.

“Allows for the correction of anemia with a 50% reduction in the doses Of Epo and Iron, and results in lower serum ß₂M levels.”
Duranti E: Long-Term Data of Patients Changing from Standard
Hemodiafiltration to Online Hemodiafiltration: Dialysis Transplant 2003; 32(2):73, 76- 9,100.

“On-line hemodiafiltration (HDF) provides the largest amount of blood purification over a wide molecular weight spectrum achievable with present renal replacement therapies.”
Ledebo I: On-Line Hemodiafiltration: Technique and Therapy. Advances in Renal Replacement Therapies 1999; 6(2): 195-208.

“I agree with Dr. Ledebo in calling for a reexamination of HF for routine use in maintaining patients with ESRD as a potentially superior modality for “laundering” uremic blood.”
Henderson L W: Hemofiltration and the Middle Molecule. Blood Purif 1999; 17: 175-177.

“We found that HF and HDF reduced DRA mortality and postponed the need for CTS surgery.”
Locatelli F, Marcelli D, Conte F, Limido A, Malberti F, Spotti D for the Registro Lombardo Dialisi & Trapianto : Comparison of Mortality in ESRD Patients on Convective and Diffusive Extracorporeal Treatments. Kidney Int 55:286-293, 1999.

“The increased efficiency of HDF over hfHD makes HDF treatment preferentially suited for larger patients who cannot attain adequate dialysis within 4 hours. This modality is also ideal for removal of ß₂-microglobulin for patients at risk of amyloidosis”
Mishkin MA, Mishkin GJ, Lew SQ: Solute Removal in Hemodialysis Compared to Standard High Flux Dialysis: Combined Analysis of 2 Cross Over
Studies (abstract): J Am Soc Nephrol 2002; 13:238A/ASN Congress, Oct.30-Nov4.

“OL HDF uses ultrapure dialysate and reinfusate with the aim of sterility and apyrogenicity and thus contributes to a reduced proinflammatory cytokine production, improving anemia.”
Bonforte G, Grillo P, Zerbi S, Surian M: Improvement of Anemia in Hemodialysis Patients Treated by Hemodiafiltration with High-Volume On-Line Prepared Substitution Fluid. Blood Purif 2002; 20:357-363.

“Vascular stability during the dialytic session is improved by convective processes, as is confirmed by a low prevalence of arterial hypertension in HDF patients.
Gonella M, Calabrese G, Pratesi G, Mazzota A, Vagelli G: Optimization of Extracorporeal Dialytic Treatment: On-line Hemodiafiltration (in Italian, abstract in English): Minerva Urol Nefrol 2001; 53(2):105-12.

“Treatment with On-line HDF with a highly permeable and biocompatible membrane has a proven to be an efficient, well tolerated and safe technique. Furthermore it leads to a low prevalence of dialysis amyloidosis and a superior P clearance.”
Lorney W, Because I, Billiouw JM, Sierens L, Van Malderen P, D’Haenens P: On-line Haemodiafiltration. Remarkable Removal of B2-microglobulin. Long-Term Clinical Observations: Nephrol Dialysis Transplant 2000; 15(suppl.1); 49-54.

“On-line HDF offers a better cardiovascular stability and clinical improvement.”
Lin CL, Huang CC, Chang CT, Wu MS, Hung CC, Chien CC, Yang CW: Clinical Improvement by Increased Frequency of On-line Hemodiafiltration: Renal Failure 2001; 23(2):193-206.

“On-line hemodiafiltration provides superior solute removal to high-flux hemodialysis over a wide molecular weight range.”
Ward RA, Schmidt B, Hullin J. Hillebrand GF, Samtleben W: A Comparison of On-line Hemodiafiltration and High-flux Hemodialysis: A Prospective Clinical Study: J AM Soc Nephrol 2000; 11(2):2344-50.

“During on-line HDF treatment, dialysis dose was increased for both small and large molecules with a decrease in uraemic toxicity level (TAC). On-line HDF provided a better correction of anaemia with lower dosages of erythropoietin. Finally, blood pressure was easily controlled.”
Maduell F, Del Pozo C, Garcia H, Sanchez L, Hdez-Jaras J, Albero MD, Calvo C, Torregrosa I, Navarro V: Change from Conventional Haemodiafiltration to On-line Haemodiafiltration: Nephrol Dialysis Transplant 1999;14(5):1202-7.

“HDF did improve the elimination of phosphate and should be considered as an additional treatment option for hyperphosphatemia in dialysis patients. HDF improves significantly the elimination of ß₂-M.”
Zehnder C, Gutzwiller JP, Renggli K: Hemodiafiltration- A New Treatment Option for Hyperphosphatemia in Hemodialysis Patients: Clin Nephrol 1999; 52(3):152-9.

“HDF with on-line production of substitution fluid provided a significantly improved Tx tolerance as compared to HFHD.”
Mishkin GJ, Mishkin M, Barlee V, Lew SQ, Bosch JP: Improved Treatment Tolerance for Patients Prone to Hypotensive Episodes using Hemodiafiltration (HDF) with On-line Production of Substitution Fluid (abstract): J Am Soc Nephrol 1999;10(9):295A/32nd Annual Meeting ASN, Miami, Nov, 1-8, 1999.

“Convective therapies such as hemofiltration, hemodiafiltration and double high-flux dialysis have been shown to improve treatment delivered and treatment tolerance when compared to conventional dialysis therapies.”
Bosch JP, Mishkin GJ: Hemofiltration and Double High Flux Dialysis: Risks and Benefits: Curr Opin Nephrol Hypertens 1998; 7(6):643-7.

“Ultrafiltration and convective clearance, a way to enhance dialysis performance and to enlarge the spectrum of uraemic toxins removed”
Canaud B, Leray-Moragues H, Bosc JY, Leblanc M: Ultrafiltration and Convective-Based Dialysis Modalities: New Trends and applications for Renal Replacement Therapy in ESRD Patients. Nephrol Dial Transplant 1999; 14 [Suppl]: 98-105.